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(BCO-0417) Inherited Blood Platelet Disorders

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Studies of the interactions among normal and abnormal blood cells and between normal and abnormal blood cells and the blood vessel wall and of genetic and functional basis of inherited platelet, white blood cell, red blood cell, and coagulation disorders.

Principal Investigator:
Barry Coller M.D.


Contact Information:
Barry Coller
Rockefeller University
1230 York Avenue
New York, NY 10065
Telephone: 212-327-7490
FAX: 212-327-7493
Enrollment Status:
Open to Enrollment

Brief Summary of Protocol:
Our goals for this study are to look at: • the interactions among normal and abnormal blood cells • the interactions among normal and abnormal blood cells & the blood vessel wall • the genetic and functional basis of inherited blood cell and coagulation disorders. We are asking you to take part in this research study because you are a normal volunteer and we need to study normal blood. Your participation will consist of: • Being asked about your general health and the medications you are taking • Donating blood • 15 minute visit(s) to the Rockefeller University Hospital Outpatient Clinic per blood donation

Detailed Description of Protocol:
The interaction of blood cells with each other and with the blood vessel wall are important in a number of different physiologic and disease processes. The long term goal of our studies is to understand these processes better to improve the diagnosis, treatment, and prevention of these bleeding disorders. We identify the genetic abnormality in patients diagnosed with Glanzmann thrombasthenia, a condition caused by lack of a protein required for platelet to clump together. This disorder may cause severe bleeding. We analyze the blood cells and plasma of healthy volunteers as well as patients with sickle cell disease to better understand the differences and the cell-to-cell interactions that contribute to disease in patients.

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

Male and Female healthy volunteers 18 years of age or older


18 years and older

Children permitted to participate:

Potential Benefits.....
There will be no direct benefits to participants. The information obtained from the study may lead to better diagnosis and treatment of bleeding disorders, sickle cell disease, heart attacks and strokes.

• $25 per donation of up to 2 tablespoons (30 ml) of blood.