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(JKR-0442) A study to document the natural course and history of psoriasis before, during and after treatment with conventional therapies

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A study to document the natural course and history of psoriasis before, during and after treatment with conventional therapies (JKR-0442)

Principal Investigator:
James G. Krueger M.D., Ph.D.


Contact Information:
Patricia Gilleaudeau
The Rockefeller University
1230 York Avenue
New York, NY 10021
Telephone: 212-327-8333
Alt. Telephone: 1-800-RUCARES
FAX: 212-327-8232
Contact Information:
Mary Sullivan-Whalen
Telephone: 212-327-7212
Alt. Telephone: 1-800-RUCARES

Enrollment Status:
Practitioner referral, special

Brief Summary of Protocol:
Psoriasis is thought to be due to an overly active immune system and has the tendency to be inherited from your parents.

We are trying to gain a better understanding of psoriasis and how it responds to various conventional treatments.

Detailed Description of Protocol:
You will be studied in one or more of the following ways.

They may be done before, during, and after any treatment is completed.

1. Blood analysis- 20 to 50 ml of blood (5-10 teaspoons) will be taken sterilely from a vein in your arm.

2. Tissue analysis- a skin biopsy will be taken sterilely from either normal or psoriatic skin.

3. Ultrasound analysis- this is noninvasive and involves using a probe applied to the skin.

4. Clinical assessment- one of the most widely accepted psoriasis assessment tools is the Psoriasis Assessment Severity Index or PASI. It involves looking at your skin and rates the amount of redness, scaling (flaking), and thickness.

5. Photographs- medical photography will be done to document disease and changes over time. Your identity will be kept confidential.

6. Skin culture- your skin will be swabbed with a culture swab and cultured for bacteria and fungus.

7. Skin scrapings- the scale of a psoriatic plaque will be gently scraped off This will cause no skin wound, bleeding, or pain. Profile:
If you join the research study, you will take part for up to one year.

The research study as a whole will last up to one year.

About 200 people will take part in the research study.

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

- Must have Psoriasis


12 years and older

Children permitted to participate:

Potential Benefits.....
There is no direct benefit to you expected from your taking part in this study.

Others may benefit in the future from what we learn in this study.

There is no compensation for participation in this research study.