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(MKR-0004) Studies of Long-Acting Opioid Metabolism, Disposition, Drug Interactions and Effects

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Studies of Long-Acting Opioid Metabolism, Disposition, Drug Interactions and Effects

Principal Investigator:
Mary Jeanne Kreek M.D.


Contact Information:
Kimberly Lake, MSN, FNP-BC
Rockefeller University
1230 York Avenue
New York, NY 10021
Telephone: 212-327-8282
Enrollment Status:
Open to Enrollment

Brief Summary of Protocol:
This research study is an attempt to learn about the long-term effects of addictive diseases and their treatment (especially with medications such as methadone, buprenorphine, and naltrexone).

The medical status of patients with addictive diseases is also being studied. Parallel studies are being carried out in subjects without addictive diseases.

By identifying medical or medication related issues affecting people with addictive diseases, the researchers hope to better understand the nature of addiction and its treatment.

Detailed Description of Protocol:
- A research physician, nurse practitioner or nurse will see you and ask about all drugs and alcohol that you may use.

- You will be asked to provide a blood sample.

- We will look at your blood to document your health status. If you are a woman of childbearing potential, you will have a serum or urine pregnancy test.

- A routine screening electrocardiogram will be performed to look at your heart status.

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

- Currently have an addictive disease


- Had an addictive disease in the past


Never had an addictive disease


18-70 years

Children permitted to participate:

Potential Benefits.....
There will be no direct benefit to you.

Instead, others may benefit in the future from what we learn from this study.

There is no cost to you for being in this research study.

You will not be paid for your participation in this research study.