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(MKR-0005) Molecular and Neuroendocrine Profile in Normal Healthy Volunteers and Volunteers with Specific Addictions

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Molecular and Neuroendocrine Profile in Normal Healthy Volunteers and Volunteers with Specific Addictions

Principal Investigator:
Mary Jeanne Kreek M.D.


Contact Information:
Kimberly Lake, MSN, FNP-BC
Rockefeller University
1230 York Avenue
New York, NY 10021
Telephone: 212-327-8282
FAX: 212-327-8574
Enrollment Status:
Open to Enrollment

Brief Summary of Protocol:
This study is an attempt to learn about the body’s stress hormones in healthy people and in people with addictive diseases.

Stress hormones are chemicals produced in all humans in order to help the body respond to stressful situations such as illness and injury, emotional stress, and stress caused by addiction.

Some of the stress hormones we are studying are: corticotropin releasing factor (CRF), adrenocorticotropic hormone (ACTH), cortisol, and beta-endorphin.

Detailed Description of Protocol:
If you are healthy and able to participate in this study you will be invited to stay in the University’s Hospital for around one week.

During this week you will be asked to complete questionnaires that ask about your mood and how you feel about yourself.

This study also uses medications to test how your stress hormones are working. You may be given medication on 3 different days while you are in the hospital.

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

- Participants without a history of addictive disease


- Participants with a history of addictive disease in remission (achieved with or without medication such as methadone, buprenorphine, or naltrexone).


18 years and older

Children permitted to participate:

Potential Benefits.....
There are no direct benefits to you expected from your taking part in this study.

Others may benefit in the future from what we learn in this study.

There is no cost to you for being in this research study.

We will give you for each full day of inpatient participation in this study and an additional upon completion of all days of participation to help pay for your costs or time spent being in our study.

You will be paid by check received either immediately or by mail upon completion of your participation of this study.