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(MKR-0055) Corticotropin Releasing Factor (hCRF) Effects and Possible Role in Addictive Diseases

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Corticotropin Releasing Factor (hCRF) Effects and Possible Role in Addictive Diseases (MKR-0055)

Principal Investigator:
Mary Jeanne Kreek M.D.


Contact Information:
Kimberly Lake, MSN, FNP-BC
Rockefeller University
1230 York Avenue
New Y ork, NY 10021
Telephone: 212-327-8282
Enrollment Status:
Open to Enrollment

Brief Summary of Protocol:
This research study is attempting to learn about the body’s stress hormones in healthy people and in people with addictive diseases.

Stress hormones are chemicals produced in all humans in order to help the body respond to stressful situations such as illness and injury, emotional stress, and stress caused by addiction.

Some of the stress hormones we are studying are: adrenocorticotropic hormone (ACTH), cortisol, prolactin, and beta-endorphin.

Detailed Description of Protocol:
If you are able to participate in this study you will be invited to stay in the University’s Hospital for about one week.

During this time you will be asked to complete questionnaires that ask about your mood and how you feel about yourself.

This study also uses medications to test how your stress hormones are working. You may be given medication on 3 different days while you are in the hospital. Profile:
If you join the research study, you will take part for about one week. The study as a whole is ongoing.

About 400 people will take part in the research study.

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

- Healthy and do not have a history of addictive disease


- History of addictive disease in remission (achieved with or without medication such as methadone, buprenorphine, or naltrexone).


18 years and older

Children permitted to participate:

Potential Benefits.....
There are no direct benefits to you expected from your taking part in this study.

Instead, others may benefit in the future from what we learn from this study.

There is no cost to you for being in this research study.

We will give you for each day of testing you complete and an additional upon completion of all test days to help pay for your costs or time spent being in our study. You will be paid by check received either immediately or by mail upon completion of your participation of this study.