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(PRY-0501) Early events in streptococcal-host interactions

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Early events in streptococcal-host interactions

Principal Investigator:
Patricia Ryan Ph.D.

Jeanne Walker ANP-C
Vincent Fischetti Ph.D.

Contact Information:
Clinical Research Support Office
1230 York Avenue
New York, NY 10065
Telephone: 1-800-RUCARES
Alt. Telephone: 1-800-782-2737
Enrollment Status:
Not yet recruiting

Brief Summary of Protocol:
We are studying how streptococci cause disease by investigating the early events of the infection process. Streptococci are bacteria, and the specific type of streptococci that we study cause a throat infection known as “strep throat”. Human saliva (salivary mucus) is one of the first substances streptococci encounter when they enter the mouth and the respiratory tract, and the purpose of salivary mucus is to clear invading bacteria. We will measure how streptococci interact with human saliva to determine how it affects streptococci and how streptococci avoid being cleared during this interaction.

Streptococcal pharyngitis (strep throat) is a common disease, and there is no vaccine to eliminate it. Our studies are designed to try to understand how streptococci cause disease. In doing so, we may be able to devise a strategy to prevent it.

We are trying to determine how streptococci interact with mucus in saliva, if the mucus in saliva differs in composition between individuals, and how these differences might effect the streptococcal interactions with it.

Detailed Description of Protocol:

What specifically makes a person eligible for the study?
You may be eligible to enter this study:


18 years and older

Children permitted to participate:

Potential Benefits.....
There will not be a direct benefit to you for participating in this study, however you will be helping us develop a method to prevent infection by streptococci, which could benefit many people, especially children, who get strep throat.