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(LHU 0616) Fructose-Induced Palmitate Synthesis in Overweight Subjects


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(LHU 0616) Fructose-Induced Palmitate Synthesis in Overweight Subjects

Principal Investigator:
Lisa Cooper Hudgins M.D.

Investigators:
Jeanne Walker ANP-C
Thomas Parker Ph.D.
Daniel M. Levine Ph.D.
Bruce Gordon M.D.
Donna Brassil M.A, R.N, CCRC

Contact Information:
Clinical Research Support Office
The Rockefeller University
1230 York Avenue
Box #327
New York, NY 10021
Alt. Telephone: 1800-RU-CARES
FAX: 212-327-8450
Email: rucares@rockefeller.edu
Enrollment Status:
Closed to Enrollment

Brief Summary of Protocol:
The purpose of the study is to learn whether a single drink of the common dietary sugar, fructose, alone or with another common sugar called glucose, will increase blood fats made by the liver, called triglycerides.
Over time, a high level of blood triglycerides, like a high level of cholesterol, may be unhealthy for the heart. Too much fructose and sugar in the diet may greatly increase blood fats in some overweight individuals, especially in those with signs of pre-diabetes.
To participate, you will have an appointment at our research center to:
-discuss the details of the study
-sign a consent form
-have a physical exam.
If you agree, you will return for:
-a fasting blood test
-a urine test
-a test to check for diabetes called a glucose tolerance test.
If the blood test results meet the requirements of the study, you will return 3 more times to the clinic at least a week apart and receive one of 3 drinks in no set order: fructose alone or fructose plus glucose in 2 different amounts. We will get a blood sample before and at 1, 2, 3 and 4h after each drink to measure levels of triglycerides and other fats and sugars.




Detailed Description of Protocol:
Profile:
1. Males and females, 18-75 years of age.
2. Body mass index (BMI) 25-35 and within 10% of maximum weight



What specifically makes a person eligible for the study?
You may be eligible to enter this study:

1. Males and females, 18-75 years of age
2. Body mass index (BMI) 25-35 and within 10% of maximum weight
3. Willing and able to stop fish oil, psyllium, other non-prescribed vitamins/supplements for 1 week prior to study until completion of study.
4. Willing to not drink alcohol for 24 h before each day of blood sampling.
Calculate_BMI

Gender:
Both

Age(s):
18 to 75

Children permitted to participate:
No

Potential Benefits.....
There are no direct benefits to participating subjects.
However, there may be future benefits to participants and society from new information which link dietary carbohydrate, high Triglycerides, diabetes and cardiovascular disease.



Compensation:
Participating subjects will receive:
-$15 for the first screening visit
-$35 for the second screening visit
-$50 for each fructose challenge for a total of $200.
Subjects will be paid by check at the completion of the study, and those not completing the study will be paid for the completed portion of the study.