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(LVO-0619) Female Responses to Exposure to Androstadienone (a Male Hormone)

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Physiological Effects of Androstadienone Exposure (LVO-0619)

Principal Investigator:
Leslie B. Vosshall Ph.D.

Jeanne Walker ANP-C
Mary Sullivan-Whalen N.P.
Barbara O'Sullivan MD, MPH
Hiroaki Matsunami Ph.D.
Andreas Keller Ph.D.
Peggy Hempstead R.N.
Iran Gomez M.D
Patricia Gilleaudeau N.P.

Contact Information:
Leslie Vosshall, Ph.D.
1230 York Avenue
New York, NY 10065
Telephone: 212-327-7635
Alt. Telephone: 1800-RU-CARES
FAX: 212-327-7238
Contact Information:
Andreas Keller
Telephone: 212-327-SMELL (7635)
Alt. Telephone: 1800-RU-CARES

Enrollment Status:
Closed to Enrollment

Brief Summary of Protocol:
The reason for doing this research is to understand why different people show different responses when they smell an odor called androstadienone. Androstadienone is a chemical found in male sweat.

Other studies have shown that smelling this chemical can cause people to experience sweating, changes in skin temperature and changes in a stress hormone called cortisol. These responses, which are called "physiological effects", are stronger in some people than in others.

We are interested in finding out whether these individual differences are genetic, that is caused by differences in our genes. Humans have about 1000 genes for odorant receptors. These are molecules that bind and detect odor molecules in our nose and allow us to respond to so many different odors.

Detailed Description of Protocol:
The study will be conducted in women age 18-35 years.

The protocol consists of five visits. The first visit is a screening visit at which the eligibility is determined and a blood sample is taken. At this visit, volunteers are given ovulation test strips and instructions to perform urine-based ovulation self-tests at home for a period of several days following the onset of menstruation.

When the volunteer ovulates and is available for a visit she will come to the Rockefeller University Hospital within one day of detecting an LH surge for the first of four Test Sessions.

The four Test Sessions are identical with the exception that the subject is exposed to a different odor stimulus.

We will be measuring:

1. Skin temperature
2. Sweating, as measured by skin conductance
3. Salivary cortisol levels
Healthy adult women:
between 18 and 35 years of age
who have NOT taken contraceptives over the last three months

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

Healthy adult women:
between 18 and 35 years of age
who have NOT taken contraceptives over the last three months


18 to 35

Children permitted to participate:

Potential Benefits.....
There will be no benefit from participating in this study. Instead, others may benefit in the future from what we learn from this study.

Participants will be compensated:

$20 for the first visit

$40 for visits 2, 3, 4 and 5

After the 5th and final visit, participants will receive an additional $40.

The total compensation for completing the study is $220.
If the Investigator needs to repeat one of the Test Visits participants will be paid an additional $40. If there are problems with the blood sample and the Investigator needs to ask for a second visit, participants will receive and additional $20.