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(SWP-0660) The Immune Response in Blood Cells of Healthy Volunteers

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Monocyte Intracellular Cytokine Production in Healthy Volunteers

Principal Investigator:
Swaroop Pendyala MD


Contact Information:
Clinical Research Support Office
Rockefeller University
1230 York Avenue
New York, NY 10065
Telephone: 1-800-RUCARES
Alt. Telephone: 1-800-782-2737
Enrollment Status:
Closed to Enrollment

Brief Summary of Protocol:
In an earlier feasibility study protocol we evaluated the effect of vitamin D replacement on intracellular cytokine production in peripheral blood monocytes in vitamin D depleted obese volunteers. Early data analysis has demonstrated an improvement in the cytokine production with vitamin D replacement. However control levels in normal healthy and obese volunteers are much needed for comparison.

This study will determine the levels of cytokine production in peripheral blood monocytes in age and gender matched healthy and obese volunteers who are vitamin D sufficient.

Detailed Description of Protocol:
The purpose of this study is to evaluate the production of cytokines by peripheral blood monocytes in healthy and obese subjects who are vitamin D sufficient.

Participation involves:
• 1 screening visit
• 1 study visit
• fasting overnight only for the study visit, and 2 blood draws (about 5 tablespoons total) Profile:
Healthy male volunteers are being recruited for this study.

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

You may qualify if you are:
• between the ages of 18 and 65
• male
• nonsmoking



Children permitted to participate:

Potential Benefits.....
Subjects will be informed of their vitamin D status. Any subject is excluded due to his Vitamin D deficiency will receive a copy of the vitamin D report and will be advised to followup wiht his primary care physican for further management.

The individual volunteer will gain a better knowledge of his health status through blood tests at no cost to him.

The subject will be compensated $15 for his screening and $25 for testing visit.

A total of $40 compensation will be given to the subject upon completion of the study.