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(MAP-0683) The Effect of Vitamin D3 Repletion on Small LDL Particle Number in Subjects at Elevated Cardiovascular Risk


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The Effect of Vitamin D3 Repletion on Small LDL Particle Number in Subjects at Elevated Cardiovascular Risk..

Principal Investigator:
Manish Ponda M.D.

Investigators:
Jeanne Walker ANP-C
Peter R. Holt M.D.
Jan L. Breslow M.D.

Contact Information:
Clinical Research Support Office
1230 York Avenue
New York, NY 10065
Telephone: 1-800-RU-CARES
Alt. Telephone: 1-800-782-2737
Email: RUCARES@Rockefeller.edu
Enrollment Status:
Closed to Enrollment

Brief Summary of Protocol:
Vitamin D is a fat-soluble vitamin that is naturally present in very few foods, added to others, and available as a dietary supplement. It is also produced in the body when ultraviolet rays from sunlight strike the skin and trigger vitamin D synthesis. Vitamin D is essential for promoting calcium absorption and maintaining adequate serum calcium and phosphate concentrations to enable normal mineralization of bone and bone growth. Without sufficient vitamin D, bones can become thin, brittle, or misshapen. Vitamin D sufficiency prevents rickets in children and osteomalacia in adults. Together with calcium, vitamin D also helps protect older adults from osteoporosis. Many people have low levels of Vitamin D. Replacing Vitamin D is thought to help lower the risk of heart disease. Vitamin D may be helpful, but it could also be harmful. The investigators are studying the effect of Vitamin D on the level of a harmful kind of cholesterol. Participants will have their cholesterol levels measured and then receive either Vitamin D or a placebo. After 2 months of treatment, the investigators will measure their cholesterol levels again.



Detailed Description of Protocol:




What specifically makes a person eligible for the study?
You may be eligible to enter this study:

You may be able to participate if you have one or more of the following: Diabetes, Obesity, Heart Disease, Kidney Disease

Gender:
Both

Age(s):
18-85

Children permitted to participate:
No

Potential Benefits.....




Compensation:
Compensation is provided.