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(DOR-0722) T Cell Activation in RA

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Evaluation of Immune Activation in Rheumatoid Arthritis

Principal Investigator:
Dana Orange M.D.

Mayu Frank N.P.
Robert B. Darnell M.D., Ph.D.

Contact Information:
Clinical Research Support Office
The Rockefeller University
1230 York Avenue
New York, NY 10065
Telephone: 1.800.RUCARES
Alt. Telephone: 1.800.782.2737
Enrollment Status:

Brief Summary of Protocol:
Rheumatoid arthritis (RA) is an autoimmune disease (condition that makes your body attack itself) that causes chronic inflammation (swelling) of the joints. Recent advances in the treatment have improved the quality of life for many people living with the disease. The goal of this study is to look at a certain type of white blood cell in people who have RA. The study is focusing on the immune response (the ability of the body to keep from getting a disease). We will assess this white blood cell by collecting and storing information on the course of your disease over time.

Detailed Description of Protocol:
Your eligibility to participate in the study will be determined form the results of the tests taken at the screening visit. You will then be contacted to be scheduled to undergo the leukapheresis procedure as a day patient in the RUH.
Leukapheresis is a procedure in which a small portion of your white blood cells are removed from your blood.. The blood is removed through a needle inserted in a vein in one arm and it will pass through a sterile tube to a machine that separates it into plasma, red blood cells, and white blood cells. The red cells and most of the plasma will be returned through a needle in the other arm or to the same arm. White cells and a small amount of plasma will be retained for use in this study. The mild reduction in your white blood cells is only temporary and not dangerous to your health. The procedure will take approximately 3–4 hours and be performed by a specially trained nurse from the New York Blood Center. An RUH nurse will be monitoring you during the procedure.
If you have RA, the Principal Investigator may call you about every 2-3 months to determine if there has been a change in your RA health status with the possibility that you may be invited to return to contribute additional white blood cells.

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

- Diagnosis of Rheumatoid Arthritis according to the American College of Rheumatology Guidelines and a Positive anti-CCP antibody test OR
- A healthy normal volunteer



Children permitted to participate:

Potential Benefits.....
There are no direct benefits to you for participating in this study. You may gain a better knowledge of your health status through the comprehensive physical examination and blood tests performed during the study. A copy of the standard New York certified laboratory tests will be made available to you if you like.

Compensation is provided