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(PHO-0735) Obesity Influence on Cancer

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Pilot: Obesity Associated Serum Derived Factors and Cancer

Principal Investigator:
Peter R. Holt M.D.

Jeanne Walker ANP-C
Jan L. Breslow M.D.

Contact Information:
Clinical Research Support Office
1230 York Avenue
New York, NY 10065
Telephone: 1-800-RUCARES
Enrollment Status:
Closed to Enrollment

Brief Summary of Protocol:
Obesity is a risk factor for poor patient outcomes in specific cancers of the breast and colon. Changes in the levels of several blood components such as insulin, molecules of inflammation and fat cells may influence tumor growth. These varying levels may tell us what effect these factors have on either the tumor itself or surrounding tissue cells. A better understanding of the link between obesity, blood levels of these factors and tumor growth could lead to new treatments. For example, if insulin is found to influence tumor growth, a drug like Metformin, which reduces insulin levels, might be useful to prevent tumor growth in the obese. To better understand the underlying biology, this study will compare the effects of blood from obese men and postmenopausal women to men and postmenopausal women of normal weight on tumor growth and possibly the surrounding tissues.

Detailed Description of Protocol:
If you join the research study, you will take part for a maximum of 2 outpatient visits. The research study as a whole will last about 2 years.

About 40 people will take part in the research study.

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

- BMI of 35-50 OR
- BMI of 20 - 24.9
- Non-smoker
- Have not been diagnosed with Diabetes
- HIV negative
- Have never been diagnosed with Hepatitis
Women participants must be post-menopausal



Children permitted to participate:

Potential Benefits.....
During this study you will have a number of clinical laboratory tests performed at no cost to you.

Compensation is provided.