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(EGU-0757) Contact Dermatitis

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A Study to Document the Natural History of Contact Dermatitis through Analysis of Immune Reactions Occurring Upon Administration of Patch Tests and Contact Dermatitis Affected Skin

Principal Investigator:
Emma Guttman MD, PhD

Mary Sullivan-Whalen N.P.
James G. Krueger M.D., Ph.D.
Nicholas Gulati
Julia Gittler
Patricia Gilleaudeau N.P.

Contact Information:
Clinical Research Support Office
The Rockefeller University
1230 York Ave.
New York, NY 10065
Telephone: 1-800-RUCARES
Enrollment Status:
Closed to Enrollment

Brief Summary of Protocol:
Allergic contact dermatitis is a term for a skin reaction resulting from exposure to specific substances that come into contact with skin that is hypersensitive (allergic) to the substance. These substances are called “allergens.” Some common allergens are nickel, rubber, dyes, poison ivy, and certain chemicals found in hair products, shoes and clothing. For some, any exposure to that specific allergen will produce a rash that may consist of redness, swelling and blisters. This rash may become worse with each exposure to the allergen. The rash occurs because the immune system, which is the body’s primary line of defense against infections and other things perceived as foreign to the body, recognizes the allergen as foreign and mounts an immune response against the body, itself. Cells that are specific to the allergen attack the skin, leading to the rash. Currently, the main treatment for allergic contact dermatitis is avoidance of the allergen.

This study hopes to improve our understanding of how the immune system acts in allergic contact dermatitis. The reason for doing this research is to better understand how the immune system is activated to produce the rash of allergic contact dermatitis, so that we can develop better treatments that may target the cells that are involved in causing the rash of allergic contact dermatitis.

Detailed Description of Protocol:
The study involves 1 screening visit to determine eligibility. If you are found eligible, you would be asked to return for approximately 9 visits over a 10 week period.

The study involves:
• Patch tests
• Blood work
• Ultrasounds
• 7 skin biopsies

The research study as a whole will last about 15 years. About 400-500 people will complete the research study.

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

• History of skin rashes from a specific product or food
• Generally healthy



Children permitted to participate:

Potential Benefits.....
You will be administered patch tests that may identify the particular allergens that cause you to develop the rash of allergic contact dermatitis. You will then be educated regarding how to avoid this allergen and further, you may be referred for symptomatic treatments for the allergic contact dermatitis, according to standard of care.

Compensation is provided for study participation.