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(MPO-0787) Oral Vitamin D vs. UV: effect on lipids

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The Effect of Oral Vitamin D vs. Narrow-Band UV-B Exposure on the Lipid Profile

Principal Investigator:
Manish Ponda M.D.

Michelle Lowes MD, PhD
Jan L. Breslow M.D.

Contact Information:
Clinical Research Support Office
The Rockefeller University Hospital
1230 York Ave.
New York, NY 10065
Telephone: 1-800-RUCARES
Alt. Telephone: 1-800-782-2737
Enrollment Status:
Closed to Enrollment

Brief Summary of Protocol:
Low levels of Vitamin D (also known as vitamin D deficiency) is a common condition and is found in about 30% of the population. A vitamin D deficiency can occur when usual dietary intake is lower than recommended levels over time, or exposure to sunlight is limited. Low levels of vitamin D in the blood are associated with heart disease risk factors, including harmful cholesterol levels. A recent study at Rockefeller University showed that when people took oral vitamin D, it failed to improve their cholesterol level. This may be due to the route of Vitamin D administration.

For this study, we will compare the effect of oral vitamin D repletion to ultraviolet (UV) light exposure on blood cholesterol.

Detailed Description of Protocol:
If you join the research study, you will take part for about 6 months. The research study as a whole will last about 5 years. About 120 people will take part in the research study.

The study involves:
- A screening visit
- Taking oral Vitamin D or receiving ultraviolet light treatment
- Up to 20 study visits at our Outpatient Research Center
- Blood draws
- Skin biopsies (optional)

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

- Have low Vitamin D
- Are generally healthy
- Are not taking Vitamin D or Cholesterol medication



Children permitted to participate:

Potential Benefits.....
The benefits you might expect from taking part in this research study are:
- You may benefit if your vitamin D level return to normal.
- You may find out during the research study that the vitamin D or UVB light therapy is helpful to you.
- You may benefit from what we learn in this research study whether vitamin D and/or UVB light therapy helps you or not.

Compensation is provided.