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(EKE-0724) Food and Anxiety

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Effect of Metabolic State on Anxiety in Human Subjects

Principal Investigator:
Ana Emiliano MD

Barbara O'Sullivan MD, MPH

Contact Information:
Clinical Research Support Office
The Rockefeller University
1230 York Avenue
New York, NY 10065
Telephone: 1-800-RUCARES
Alt. Telephone: 1-800-782-2737
Enrollment Status:
Not yet recruiting

Brief Summary of Protocol:
The purpose of this study is to examine the relationship of stress and eating patterns in normal weight and obese participants. In the United States alone, it is estimated that at least 40 million people have anxiety disorders and 70 million people are considered obese. Interestingly, many people tend to have symptoms of both anxiety and disordered eating at the same time, suggesting that there may be a connection between anxiety and food intake. It is not known if anxiety impairs an individual’s ability to diet, by increasing hunger and preference for foods rich in sugar and fat. In other words, we are trying to find out if dieting (fasting) increases anxiety and whether anxiety increases appetite, therefore creating a vicious cycle.

To better understand the relationship between anxiety and food, we are studying the effect of changes in food consumption on anxiety in obese and normal weight people. We will be studying people while fed and fasted and also when anxious. We expect that the findings of this study will provide us with more information about how someone’s nutritional state changes how the brain works and this may help us develop more effective treatments for obesity. Also, this study may give insight to anxiety and eating disorders.

Detailed Description of Protocol:
If you join the research study, you will take part for up to 2 months. The research study as a whole will last about 4 years. About 100 people will take part in the research study.

Study participation involves:
- 2 screening visits to see if you qualify
- 2, 3-day inpatient stays in our Research Hospital (with a private room and cable TV)
- Questionnaires
- Blood draws
- MRIs

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

- Body Mass Index (BMI) from 19.0 to 25.0 for the lean population
-Body Mass Index (BMI) equal to or greater than 30 for the obese population and under 300lbs.
(To calculate your BMI visit:
- Healthy
- Non-smoker
- Right-handed



Children permitted to participate:

Potential Benefits.....
During this study, you will have multiple laboratory tests, at no cost to you. If any abnormalities are discovered during clinical testing, you will be made aware and a copy of the lab results will be made available to you.

Compensation is provided for participation.