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(EWE-0827) Autoantibodies and cancer


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Identification of autoantibodies targeting genes implicated in metastatic cancer

Principal Investigator:
Ethan Weinberg

Investigators:

Contact Information:
Recruitment Specialist
1230 York Avenue
New York, NY 10065
Telephone: 1800RUCARES
Alt. Telephone: 1800RUCARES
Email: rucares@rockefeller.edu
Enrollment Status:
Open to Enrollment

Brief Summary of Protocol:
Despite advances in medicine in the treatment of cancer, it is still the second-leading cause of death in the United States. The immune system is the body’s defense against foreign invaders such as viruses and bacteria. Antibodies are one part of the immune system. Autoantibodies are antibodies made by the body that work against one’s own cells and tissues. We know that people with lupus produce autoantibodies, and that some individuals who have breast and colon cancer produce autoantibodies. We don’t know which individuals with breast and colon cancer produce autoantibodies. The reason we are doing this study is to better understand the role of autoantibodies in cancer.



Detailed Description of Protocol:




What specifically makes a person eligible for the study?
You may be eligible to enter this study:

1) diagnosed with SLE, as documented by provider with current thrombocytopenia (platelet count <150,000mm3 within 6 months of screening) OR 2) Recently diagnosed colorectal cancer or breast cancer – diagnosed within one year of enrollment and substantiated by physician documentation with accompanying pathology report or cross-sectional imaging (computed tomography, magnetic resonance imaging, or positron emission tomography). OR 3) A history of advanced colorectal cancer or breast cancer. Advanced colorectal cancer will be defined as colorectal cancer spread to lymph nodes or distant organs. Advanced breast cancer will be defined as breast cancer that has spread to more than three lymph nodes or to distant organs. This diagnosis will require substantiation by physician documentation with accompanying pathology report or cross-sectional imaging (computed tomography, magnetic resonance imaging, or positron emission tomography).

Gender:
Both

Age(s):
18 and up

Children permitted to participate:
No

Potential Benefits.....
no direct benefit



Compensation:
compensation is provided