Clinical Studies and Protocols
Site Map Investigators Log-inClinical Studies and Protocols
Click below for more details or search for keywords above
(JHS-0922) Developing an improved test for detecting impaired sense of smell


General olfactory threshold and olfactory resolution test: A diagnostic accuracy study
Principal Investigator:
Julien W. Hsieh MD
Investigators:
Contact Information:
Principal Investigator:
Julien W. Hsieh MD
Investigators:
Contact Information:
Recruitment Specialist
1230 York Avenue
New York, NY 10065
1230 York Avenue
New York, NY 10065
Telephone: 1800RUCARES
Email: RUCARES@Rockefeller.edu
Email: RUCARES@Rockefeller.edu
Enrollment Status:
Completed/Closed
Brief Summary of Protocol:
It is important to have an effective test because an impaired sense of smell can lead to negative consequences on quality of life. One problem of measuring whether somebody has a reduced sense of smell is that healthy people are frequently insensitive to single molecules. Healthy people cannot detect single molecules because of differences in genetic background, which is not related to health issues. Despite this, the most commonly used diagnostic smell tests utilizes single molecules. Another problem is that these tests are based on odors that are familiar to a single population of reference. Familiarity to odors varies largely between cultures and countries. Therefore, people that culturally differ from this population of reference would score poorly on these tests despite their normal sense of smell. Despite this, the most widely used smell test largely depends on familiarity with odors. We addressed these two problems by developing universal smell tests based on unfamiliar smells and mixtures of odorants. They are named “olfactory resolution test” and “general olfactory threshold test”. In a previous study, we demonstrated that these tests were reliable. The goal of this protocol is to show that our test can accurately detect people who have lost some or all their sense of smell.
Detailed Description of Protocol:
What specifically makes a person eligible for the study?
You may be eligible to enter this study:
-partial or total loss of the sense of smell -fluent in English
Gender:
Both
Age(s):
18-100
Children permitted to participate:
No
Potential Benefits.....
There is no known benefit to participants.
Compensation:
Compensation is provided.
Completed/Closed
Brief Summary of Protocol:
It is important to have an effective test because an impaired sense of smell can lead to negative consequences on quality of life. One problem of measuring whether somebody has a reduced sense of smell is that healthy people are frequently insensitive to single molecules. Healthy people cannot detect single molecules because of differences in genetic background, which is not related to health issues. Despite this, the most commonly used diagnostic smell tests utilizes single molecules. Another problem is that these tests are based on odors that are familiar to a single population of reference. Familiarity to odors varies largely between cultures and countries. Therefore, people that culturally differ from this population of reference would score poorly on these tests despite their normal sense of smell. Despite this, the most widely used smell test largely depends on familiarity with odors. We addressed these two problems by developing universal smell tests based on unfamiliar smells and mixtures of odorants. They are named “olfactory resolution test” and “general olfactory threshold test”. In a previous study, we demonstrated that these tests were reliable. The goal of this protocol is to show that our test can accurately detect people who have lost some or all their sense of smell.
Detailed Description of Protocol:
What specifically makes a person eligible for the study?
You may be eligible to enter this study:
-partial or total loss of the sense of smell -fluent in English
Gender:
Both
Age(s):
18-100
Children permitted to participate:
No
Potential Benefits.....
There is no known benefit to participants.
Compensation:
Compensation is provided.