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(TEV-0917) Neurodegeneration in HIV and Aging


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Developing Directly Reprogrammed Human Neurons to Investigate the Molecular Basis of Neurodegeneration in HIV and Aging

Principal Investigator:
Teresa Evering M.D.

Investigators:

Contact Information:
Clinical Research Support Office
1230 York Avenue
New York, NY 10065
Telephone: 212-327-7722
Email: RUCARES@Rockefeller.edu
Enrollment Status:
Open to Enrollment

Brief Summary of Protocol:
Researchers at the Rockefeller University Hospital want to learn more about why there may be an increased decline in the neurocognitive ability of some HIV-infected versus HIV-uninfected individuals. By obtaining a small amount of skin via a skin biopsy, from younger (18-40 years of age) and older (50-74 years of age) individuals, the researchers will be able to create patient-derived neurons which retain the aging-associated features of that individual. We will then compare these characteristics in both HIV-infected and uninfected individuals from both age groups to learn the differences between both groups and both age ranges. We are asking you to take part in this research study if you are an HIV-infected individual on combination antiretroviral therapy for at least a year and have an undetectable viral load or are an HIV-uninfected individual between 18 and 40 years of age or between 50 and 74 years of age and are willing to undergo blood draws, a skin biopsy, neuropsychological testing, and complete health-related questionnaires.



Detailed Description of Protocol:




What specifically makes a person eligible for the study?
You may be eligible to enter this study:

- 18-40 or 50-74
- HIV-positive cohort: On treatment for at least 1 year
- Never had a diagnosis of Hepatitis B or C


Gender:
Both

Age(s):
18-40 or 50-74

Children permitted to participate:
No

Potential Benefits.....
There are no benefits to you for participating in this study other than the ability to obtain routine blood test results (CD4+ T-cell and HIV-1 RNA if you are an HIV+ individual) at no costs to you. Instead, others may benefit in the future from what we learn from this study.



Compensation:
Compensation is provided