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(RRU-0952) Identifying the Initial Triggers of Multiple Sclerosis (MS)

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Identifying the Initial Triggers of Multiple Sclerosis (MS)

Principal Investigator:
Rashid Rumah MD, PhD


Contact Information:
Clinical Research Support Office
1230 York Avenue
New York, NY 10065
Telephone: 1.800.RUCARES
Enrollment Status:
Open to Enrollment

Brief Summary of Protocol:
Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). In MS, the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between the brain and the rest of the body. Eventually, the disease can cause the nerves themselves to deteriorate or become permanently damaged. Signs and symptoms of MS vary widely and depend on the amount of nerve damage and which nerves are affected. Some people with severe MS may lose the ability to walk independently or at all, while others may experience long periods of remission without any new symptoms. Exactly how the brain vessels and tissues are damaged in MS is unknown. The researchers are looking at a bacterium that is sometimes found in the human gut and produces a toxin. The toxin is being studied as a possible cause of MS. Researchers will collect blood from patients who have MS and are experiencing a relapse of symptoms, as well as from healthy volunteers. Blood from all participants will be tested both for the presence of the bacterial toxin and for changes in the red blood cells due to the toxin. The researchers will compare the blood findings from MS patients with the blood findings from healthy volunteers. The researchers hope to identify a cause of MS that could eventually lead to treatments to prevent damage to the brain and nervous system. We are asking you to take part in this research study because you are a healthy volunteer who does not have MS. Your blood samples will be compared to the blood samples from MS patients. This is also known as being a “healthy control.”

Detailed Description of Protocol:
This study involves one visit. Your vital signs (pulse, respiration rate, blood pressure) will be measured. You will be asked about your medical history and any medications that you take. You will be asked to complete a medical health questionnaire. You may possibly have a targeted physical examination. A research blood sample will be drawn. The amount of the blood drawn is 22 ml, which is about 4¼ teaspoons.

What specifically makes a person eligible for the study?
You may be eligible to enter this study:

- At least 18 years old
- In good general health



Children permitted to participate:

Potential Benefits.....
There will be no benefit to you. Instead, others may benefit in the future from what we learn from this study.

Compensation is provided.